Sugar vs. Sweeteners
Sugar molecules activate a unique gut brain circuit that influences our preference for sweetness, while artificial sweeteners fail to engage this system. The sensors in the gut are specifically designed to recognize glucose, not artificial alternatives, which explains why these sweeteners don't satisfy our cravings. This disconnect may be why artificial sweeteners have not successfully curbed our desire for sugar.In this clip
From this podcast

Huberman Lab
Dr. Charles Zuker: The Biology of Taste Perception & Sugar Craving | Huberman Lab Podcast #81
Related Questions
How does the gut communicate with the brain in relation to the episode Dr. Charles Zuker: The Biology of Taste Perception & Sugar Craving | Huberman Lab Podcast #81 and the clip Sugar and Craving?
How does the gut communicate with the brain in the context of the episode Dr. Charles Zuker: The Biology of Taste Perception & Sugar Craving | Huberman Lab Podcast #81 and the clip Gut-Brain Axis?